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• Fillingim et al119 provided instructions designed to manipulate females’ and males’ perceived ability to tolerate ischemic pain, hypothesizing that enhancing perceived ability would produce greater effects in females, because males report higher perceived ability to tolerate pain at baseline.
• Ritter et al329 followed a large sample of patients that received a total knee arthroplasty for 5 years.
• The impact of sex hormones on pain responses can be broadly dichotomized into peripheral versus central nervous system effects, which are discussed below.
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• We have also discussed multiple “biological” and “psychosocial” mechanisms that may contribute to sex differences in pain and analgesic responses, including gonadal hormones, endogenous pain modulatory systems, gender roles, and cognitive/affective factors.

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• Most of the studies reviewed above address quantitative differences, which refers to whether females and males display different amounts of pain or analgesia.
• A family study recently reported that 46,XY persons with a 178 kb duplication in a region about 500 kb upstream of SOX9 were completely normal fertile males, whereas 46,XX SRY-negative persons in the same family with duplications were clinically infertile males6).
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46,XX male syndrome was first described in ), and the Chicago consensus renamed of this syndrome as 46,XX testicular DSD in ). Most patients have normal male phenotypes at birth, and are usually diagnosed in late adolescence because of delayed puberty, gynecomastia, or infertility2). Approximately 15% of XX males have hypospadias, cryptorchidism, or more severe genital ambiguity13). All 46,XX males are infertile owing to the absence of the azoospermia factor region in the long arm of the Y chromosome14,15).

SOX9 is a transcription factor with a DNA-binding site very similar to SRY, and plays a crucial role in the cascade of gene interactions for differentiation and development of the testis3). In 1999, SOX9 overexpression in a 46,XX gonad was identified as leading to an induction of male genitalia in the absence of SRY4). Although there have been a few reports to date of 46,XX SRY-negative patients having duplication of SOX94,5,6,7), SOX9 duplication is not a common cause of 46,XX testicular DSD8). In Korea, less than 10 SRY-positive 46,XX patients have been reported, and there are no reports of 46,XX testicular DSD resulting from SOX9 duplication9). Anime AI uses advanced AI algorithms and generative models to create original anime or manga art based on user inputs.

The 46,XX testicular disorder of sex development (DSD), also known as 46,XX male syndrome, is a rare form of DSD and clinical phenotype shows complete sex reversal from female to male. The sex-determining region Y (SRY) gene can be identified in most 46,XX testicular DSD patients; however, approximately 20% of patients with 46,XX testicular DSD are SRY-negative. The SRY-box 9 (SOX9) gene has several important functions during testis development and differentiation in males, and overexpression of SOX9 leads to the male development of 46,XX gonads in the absence of SRY. In addition, SOX9 duplication has been found to be a rare cause of 46,XX testicular DSD in humans.

The SRY gene plays a critical role in the initiation of testicular differentiation in males18). In XY embryos, SRY, which is normally located on the Y chromosome, induces the gonadal primordia to develop into testes. If a fetus is conceived from a sperm with an SRY-bearing X chromosome, it will develop as a male despite not having a Y chromosome.

«Master of my domain» became a part of the American lexicon from this episode. Nk,[167] «So Happy I Could Die» by Lady Gaga, «Masturbating Jimmy» by The Tiger Lillies, «When Life Gets Boring» by Gob, «Daybed» by FKA Twigs, «Get a Grip» by Semisonic, and «Darling Nikki» by Prince. The 1983 recording «She Bop» by Cyndi Lauper was one of the first fifteen songs ever required to carry a Parental Advisory sticker for sexual content.[168] In a 1993 interview on The Howard Stern Show, Lauper claimed she recorded the vocal track in the nude.[169] The song «Masturbates» by rock group Mindless Self Indulgence also deals with the concept of auto-erotic activity in a punk framework. Masturbation aids such as a vibrator, dildo, or Ben Wa balls can also be used to stimulate the vagina and clitoris. Many women caress their breasts or stimulate a nipple with the free hand and anal stimulation is also enjoyed by some. Personal lubricant is sometimes used during masturbation, especially when penetration is involved, but this is not universal and many women find their natural lubrication sufficient.

Two studies reported that sex differences in temporal summation to heat156 and mechanical361 stimulation persisted in clinical pain populations with low back pain and temporomandibular disorders, respectively. Thus, on balance, the evidence supports the conclusion that temporal summation is greater among females than males. A recent meta-analysis on sex differences in osteoarthritis using clinical markers as the case definition (not pain) indicated that females are at significantly increased risk for osteoarthritis (OA) in the knee and hand compared with males.382 Several studies have documented sex differences in pain prevalence, ratings, and depression in OA, and we will review selected studies below. NSFW Character AI represents a groundbreaking advancement in traditional AI chat technology, introducing a nsfw chat bot specifically designed for users to explore their NSFW character fantasies without restraint. This advanced platform not only facilitates a liberating space for expression but also comes equipped with sophisticated character creation tools and an intuitive interface, making it an ideal adult AI companion. As a safer and more appropriate option, platforms explicitly designed to host NSFW content should be sought.